Heterologous chimpanzee adenovirus vector immunizations for SARS-CoV-2 spike and nucleocapsid protect hamsters against COVID-19Article Published on 2023-05-012023-07-11 Journal: Microbes and infection [Category] COVID19(2023년), [키워드] adenovirus vector vaccines COVID-19 vaccine Hamster challenge model nucleocapsid protein spike protein. [DOI] 10.1016/j.micinf.2022.105082 PMC 바로가기
Nucleoside Analogs and Perylene Derivatives Modulate Phase Separation of SARS-CoV-2 N Protein and Genomic RNA In VitroArticle Published on 2022-12-032023-07-11 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), [키워드] nucleocapsid protein phase separation RNA SARS-CoV-2 small-molecule antivirals. [DOI] 10.3390/ijms232315281 PMC 바로가기
Repertoires of SARS-CoV-2 epitopes targeted by antibodies vary according to severity of COVID-19코로나19 중증도에 따라 항체 표적 SARS-CoV-2 에피토프 레퍼토리 달라Article Published on 2022-12-012022-09-11 Journal: Virulence [Category] COVID19(2023년), SARS, 진단, 치료법, [키워드] antibodies antibody Antigen association Asymptomatic asymptomatic individual asymptomatic infection Betacoronavirus betacoronavirus Community convalescent correlated COVID-19 COVID-19 severity develop diagnosed diagnostics disease severity domains Epitopes Evidence evidence of finding FIVE five groups HKU1 Hospitalization IgG IgGs Immunity immunogenic immunogenic peptide individual Infection less MERS-CoV nucleocapsid protein Nucleocapsid proteins OC43 participant pathogenic pathogenic mechanisms peptide peptide array peptides pilot study predicted Protein RBDs reaction Receptor binding domain Region repertoire SARS-CoV RBD SARS-CoV RBDs SARS-CoV-2 SARS-CoV-2 epitope SARS-CoV-2 epitopes seroconverted Seroprevalence seroprevalence. severity severity of COVID-19 symptomatic symptomatic COVID-19 symptomatic infection therapeutic therapeutic antibodies Vaccines Viral with COVID-19 without symptoms [DOI] 10.1080/21505594.2022.2073025 PMC 바로가기 [Article Type] Article
COVID-19 variants’ cross-reactivity on the paper microfluidic particle counting immunoassayArticle Published on 2022-11-012022-11-15 Journal: Analytical and bioanalytical chemistry [Category] SARS, 변종, 진단, 치료기술, [키워드] Care COVID-19 COVID-19 pandemic cross-reactivity Delta delta variant demonstrated Determining dominant variant evaluated immunoassay Microscope monoclonal antibody mutated Mutation nucleocapsid nucleocapsid antigen nucleocapsid protein Nucleocapsid proteins omicron paper Paper microfluidic chip recognizing reported SARS-CoV-2 Smartphone Smartphone microscope. Spike protein Spike proteins the disease variant variants virus [DOI] 10.1007/s00216-022-04333-8 PMC 바로가기
Sensitivity of anti-SARS-CoV-2 nucleocapsid protein antibody for breakthrough infections during the epidemic of the Omicron variantsArticle Published on 2022-11-012022-11-15 Journal: The Journal of Infection [Category] SARS, 변종, 진단, [키워드] anti-SARS-CoV-2 antibody Breakthrough infection nucleocapsid protein omicron the epidemic variant [DOI] 10.1016/j.jinf.2022.08.015 PMC 바로가기
Smartphone-Based Electrochemical Immunoassay for Point-of-Care Detection of SARS-CoV-2 Nucleocapsid ProteinArticle Published on 2022-11-012022-11-15 Journal: Analytical Chemistry [Category] COVID19(2023년), SARS, 치료기술, [키워드] antibody bovine calculated coated with Concentration detection detection efficiency diagnose Diagnosis effective electron transfer facilitate immunoassay lack less limit of detection linear N protein nucleocapsid protein offer point-of-care provided R 2 reduced reducing reported resulting SARS-CoV-2 SARS-CoV-2 N protein serological serum albumin the SARS-CoV-2 transmitted virus transmission [DOI] 10.1021/acs.analchem.2c03606 PMC 바로가기
Prevalence of antibodies against SARS-CoV-2 in the Norwegian population, August 2021Article Published on 2022-11-012022-11-15 Journal: Influenza and Other Respiratory Viruses [Category] COVID19(2023년), SARS, 진단, [키워드] absence age Anti-nucleocapsid antibodies antibody automatically children collected conducted confirmed COVID-19 case contributed COVID-19 COVID-19 case COVID-19 pandemic COVID-19 vaccination CrI cross-sectional cumulative estimate Estimated flow cytometric IgG antibody individual Infection Laboratory National Norway nucleocapsid nucleocapsid protein Prevalence RBD Receptor binding domain registry data residual SARS-CoV-2 SARS-CoV-2 antibody SARS-COV-2 infection SARS-CoV-2 seroprevalence sera seropositive sample Seroprevalence the spike protein vaccination vaccination. were measured women [DOI] 10.1111/irv.13024 PMC 바로가기
In silico characterization of mutations circulating in SARS-CoV-2 structural proteinsArticle Published on 2022-11-012022-11-16 Journal: Journal of biomolecular structure & dynamics [Category] SARS, 변종, [키워드] Algorithm Analysis caused circulating computational approach computational tool COVID-19 D614G death Deleterious discrete molecular dynamics DMD envelope protein full-length identify infections meta-data molecular molecular simulations mutant Mutation mutations N protein Neutral NMA non-structural protein normal mode analysis Nsp3 nucleocapsid nucleocapsid protein pandemic predicted Protein protein coding gene protein stability Proteins RdRP RNA-directed RNA polymerase SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genomes sequence Seven Spike protein stability structural protein suggested utilised viral dynamics viral genome viral pathogenicity Viral pathogenicity. [DOI] 10.1080/07391102.2021.1908170 PMC 바로가기
Coronavirus Antibody Responses before COVID-19 Pandemic, Africa and ThailandArticle Published on 2022-11-012022-11-15 Journal: Emerging Infectious Diseases [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] acute respiratory syndrome Affect Africa Antibody Response Antigen collected coronavirus coronavirus coronavirus disease Coronaviruses country COVID-19 COVID-19 pandemic distribution Endemic HIV-1 human SARS-CoV-2 IgG response immune response Kenya less Middle East monoclonal antibody much higher Nigeria nucleocapsid protein participant Participants populations Profiling Protein respiratory infections respiratory syndrome coronavirus response SARS SARS-CoV-1 SARS-CoV-2 SARS-CoV-2 spike screened Serosurvey serum and plasma severe acute respiratory syndrome coronavirus 2 significantly more subunit tested Thailand the receptor-binding domain Uganda Vaccine viruses zoonoses zoonoses. [DOI] 10.3201/eid2811.221041 PMC 바로가기
Sensitive Serology Measurements in the Saliva of Individuals with COVID-19 Symptoms Using a Multiplexed ImmunoassayArticle Published on 2022-10-292022-11-15 Journal: The journal of applied laboratory medicine [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] acute respiratory syndrome Antigen benefit causative pathogen collected controls coronavirus coronavirus disease COVID-19 cut-off detect Diagnosis domain group IgG individual individuals with COVID-19 infected individual infected individuals levels of antibody measurement multiplex serology multiplexed immunoassay N-terminal domain nucleocapsid nucleocapsid protein PSO Receptor-binding domain ROC ROC AUC Saliva salivary SARS-CoV-2 sensitive sensitivity Seroconversion serology specificity subjects uninfected uninfected control with COVID-19 [DOI] 10.1093/jalm/jfac073 PMC 바로가기